TFAMe is colorless and a very volatile liquid, slightly pungent and easily inflammable.
Chemical reactions and applications The esters of trifluoroacetic acid are specialties in organic syntheses. The chemical reactions are mainly based on a nucleophilic substitution of the ester and lead to formation of trifluoroacylated compounds. The most important reactions are the ester condensation for the syntheses of β-diketones, the trifluoroacylation of amines, the reaction with phosphine derivatives and the reaction with organometallics for the syntheses of fluorinated ketones and fluorinated tert. alcohols.
Delivery and handling
TFAMe is delivered in polyethylene-lined metal drums. It is an inflammable, irritante liquid. When handling TFAMe, contact with skin and inhalation of the vapours of these extremely volatile compounds must be avoided at all cost and protective clothing must be worn. Affected parts of the body must be immediately rinsed with plenty of running water. A well ventilated working area is essential.
TFAMe is colorless and a very volatile liquid, slightly pungent and easily inflammable.
