Trifluoroacetic acid (TFA) is a very hygroscopic colorless liquid. It is miscible with alcohols, ethers, acetones, halogenated hydrocarbons, benzene and fluorinated solvents. In water, trifluoroacetic acid is almost completely dissociated and, therefore, a strong organic acid (K25 = 0.59). The trifluoro methyl group does not hydrolyse.
Chemical reactions and applications Trifluoroacetic acid is used as a typical building block as well as a solvent and catalyst for polymerisation and condensation reactions.
Delivery and handling
Trifluoroacetic acid is supplied in polyethylene-lined metal drums (30, 50, 250 kg). It reacts corrosively on rubber, cork and many metals. Storage must be in well ventilated areas and care must be taken to ensure that the containers are completely sealed. As a result of its strong acidity, Trifluoroacetic acid attacks the skin and can cause severe burns. When handling Trifluoroacetic acid, gloves and protective eyeshields must always be worn. The handling area must be well ventilated. Contact with eyes, skin and clothing must be avoided. Any affected parts of the body must be rinsed immediately with lots of running water and diluted sodium carbonate solution. Contaminated clothing must be removed at once. Medical attention must be sought without delay.
Toxicological data
TXDS:
orl-rat LD50:
200 mg/kg
14 CYAT 2,1802,63*
ipr-mus LDLo:
150 mg/kg
TXAPA9 15,83,69**
*14 CYAT:
Industrial Hygiene and Toxicology, F.A. Potty, 2nd Ed., New York, Interscience, 1963
** TXAPA9:
Toxicology and Applied Pharmacology (Academic Press 111 5th Ave., New York, NY 10003) V.I
