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2,2,2-Trifluoroethanol (TFE)

 
Molecular formula : C2H3F3O
CAS : 75-89-8
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2,2,2-Trifluoroethanol (TFE) is a colorless liquid which is fully miscible with water. Because of the high electronegativity of the fluorine atoms 2,2,2-trifluoroethanol has a stronger acid character than ethanol. Due to this there is a stronger tendency to form hydrogen bridging and this makes possible the production of more stable complexes with heterocycles such as THF and pyridine. By oxidation 2,2,2-trifluoroethanol is converted to trifluoroacetaldehyde or trifluoroacetic acid.

Delivery and handling
2,2,2-Trifluoroethanol is supplied in polyethylene-lined metal drums. Inhalation and skin contact are to be avoided. Trifluoroethanol is inflammable and has a flash point of 33 °C. Furthermore, contact with the eyes is to be avoided at all costs. According to the latest experiments, it must be assumed that 2,2,2-Trifluoroethanol is a strong eye irritant which can cause irreparable damage. Below a concentration of 10 ppm no significant harmful effects have been recorded.

Toxiclogical data

IRDS:  skn-rbt 50 mg/24H SEV    28ZPAK -78,72* 
  eye-rbt 20 mg/24H SEV    28ZPAK -78,72* 
  
TXDS:    orl-rat LDLo: 2000 mg/kg    29ZPAK -78,72* 
  orl-mus LD50: 366 mg/kg      TXAPA9 15,83,69** 
  ihl-mus LC50: 1,6 %/10 M  RTECS 81/82 
  ipr-mus LD50: 195 mg/kg APTOA6 28,299,70*** 
  ivn-dog LDLo: 400 mg/kg    TXAPA9 15,83,69** 

 

 

 

 

 

 

Lit: ** TXAPA9: Toxicology and Applied Pharmacology. (Academic Press, 111 5th Ave., New York, NY 10003) V.1
*28 ZPAK:   Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku, J. V. Marhold, Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
***APTOA6:

Acta Pharmacologica et Toxicologica. (Munksgaard, 35 Norre Sogade, DK 1370 Copenhagen, K. Denmark) V.1, 1945

 

 

 

 

Availability
t-lots

HS.Code No.
29055020


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